The unfortunate truth is that it might.
Bracketologist have determined one of the main factors the committee looks at for teams on the bubble is the raw number of wins. Iowa State is not going to struggle with the other criteria -- e.g., the strength of schedule, Q1 wins, avoiding bad losses, etc. -- given the difficulty of its schedule. The schedule is so difficult that it might struggle on the win total criterium, though, which is why collecting all those free wins against cupcakes like UNO and splitting non-con games with peer P6 (win SJU, loss Iowa) squads is so important.
Look upon me and despair --
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If Iowa State ends up with 17 wins and they're in the NIT or maybe Dayton, this will be why.
You always bring the numbers that force me to think! Bottom line, there is risk in giving away an easy win.