Since I have no other basis for a score prediction, I'll just average the result of the past 10 matchups (rounded to nearest whole number, of course!):
Iowa State 23, UNI 15
I understand the FCS success and intrastate emotion aspect with UNI, so we probably can't expect frequent blowouts as the series continues.
But in the Rhoads-changing-the-culture context, ISU-UNI has to be more of a formality. Build a 24-point lead in the first half/early second half, develop some rhythm with the starting unit, be able to rest key players and get playing time for backups.
I can handle a 31-17 game that "should been" something like 35-10. Those 20-19/17-10 barnburners (even worse, losses) need to become extremely rare.