Go over to the EIU boards and they are in heaven over there with the prospect that ISU will end up in the MAC, MW, or AAC. Its not going to happen, but they love just the thought of it.
I could see the Big 10 and the Pac 12 trying to form some type of scheduling for the nonconference games, if that happens then the CyShawk game would be finished. EIU is playing the 4 one year 5 the next home conference schedule like we were. The 4 year each school hosted the game between us, and that allowed each to schedule two creampuff home games to get to 7 home games. If this scheduling between the Pac 12 and Big 10 goes through, then EIU's conference schedule rotation stays the same, but the two cream puffs become a home and away with 2 Pac 12 teams. EIU would want to keep 7 home games a year, and thereby telling ISU we will play you, but only if the game is in Iowa City, and then not every year, because we need a cream puff every now and then to get wins.
I would guess ISU would tell them to go to hell, and the yearly game would end at that point.