How do you have Vanderbilt as the toughest game? No way. Gonzaga would be if they played them by far. And Iowa number 3? No. And just because Cincinnati is at home I wouldn't put them outside of the 3 most difficult non con games. They are going to be good.
I could see switching order or 1 & 2, certainly (swapping order of any couplet, as far as that goes.) Gonzaga should be better than Vandy, on paper, but I also nudge most road games slightly tougher than neutral/home.
That's also a factor that I have Cincinnati that low, even though I expect it to have roughly same seeding area projection as ISU for NCAA tournament). Similar reasoning for Drake as high as 6th — neutral in-state game (and Drake has been known to beat good Iowa State teams, some years).