Nobody seriously hurt. And just to add insult to injury, the tire comes back and smacks the car one more time...
Couple of years ago I saw a tire come off a semi from the opposite direction. When the tire hit the first pothole/bump, it went flying at least 70-80 feet up in the air. Landed in the ditch and wobble/bounced into the woods. This was on I-80 east of Merle Hay Rd.