Notwithstanding last year's heartbreaking loss to UIC, Northwestern is the top brand in Chicagoland college basketball. At least for now. DePaul could make some noise if they get their arena in Lincoln Park and a greasy coach, though. I was sad to see Carmody go, but I think Collins will be quite a step up and he should get the program back on track after a rough 2012-2013 season.
A win for Iowa State would really help recruiting in Chicago, but you would probably be better off playing Illinois. They have a lot of "fans" (as in people who didn't go there and have no affiliation with the school other than cheering for the basketball team when they are good) when basketball season starts and so I think beating them would give you more exposure than beating Northwestern.