After quick read, the changes appear reasonable, especially considering the mega-conference trend.
I'll have to reassess after some consideration. The top-4 teams from a league in the seeding process looks to make sense on the surface, I'd have to think a bit on that.
As VeloClone noted, I like the no pre-Elite 8 matchups until more than 8 teams from a conference, but I'm sure with expansion that's becoming a headache. I think it should still be among the goals, but true seeding and geography probably should take precedence.
I also think some of the intra-conference bracketing difficulties may stem from the play-in additions (I'd have to check the rules again — maybe those weren't factored into the old rules??).
It doesn't apply to this round of changes (and I won't elaborate in this thread), but some of the regional placement and seeding also can be limited by pre-determined sites. Maybe they'll address that next year.